Also seems to be resolved in :   System Version: macOS 12.0.1 (21A559)   Kernel Version: Darwin 21.1.0 Been running a week or so with 12.0.1 and back connected to the CalDigit USB-C Pro Dock - single cable Thunderbolt 3 docking, leveraging both DisplayPort connectors at 4k @ 60Hz. It takes an insanely long time for the monitors to re-sync after blanking (I think I prohibit sleep), but no more panics. However, now web-cams plugged in via the Thunderbolt 3 dock - no longer work. With a simple passive USB-C -> USB-A adaptor, they do work fine. sigh. (so much for single cable docking).